A 74 yo attorney presented with a five year history of memory loss and word finding difficulty. His family history was positive for dementia in his mother, beginning at the age of 75 years. He had been evaluated at an Alzheimer's disease centre at the onset of his memory loss, and was found to be ApoE 4/4, with MRI showing ventricular enlargement and temporal lobe atrophy, right > left, and FDG-PET showing reduced glucose utilisation in the temporal lobes and the precuneus, compatible with Alzheimer's Disease. Neuropsychological testing was compatible with a diagnosis of amnestic MCI. He was treated with donepezil, memantine and intravenous immunoglobulin, and his MMSE fell from 27 to 23 over three years. He noted no improvement with the treatment.
He began the program, and after six months, his MMSE was 29. He returned three months later, and his MMSE was 30. He then returned three months after that, complaining that he had taken a trip, gone off much of the protocol, come under stress, and that he felt his memory had declined. His MMSE had decreased to 28. Over the ensuing 12 months on the program, his MMSE remained at 30.
Reversal of Cognitive Decline in Alzheimer's Disease. Dale E. Bredesen et al. Aging, June 2016, Vol 8 N 6.