A 69 year old entrepreneur and professional man presented with 11 years of slowly progressive memory loss, which had accelerated over the past one or two years. At age 58, he had been unable to recall the combination of the lock on his locker, and he felt that this was out of the ordinary for him. At age 59, a FDG-PET brain scan was reported as showing early Alzheimer's Disease, with reduced glucose utilisation in the parietotemporal cortices bilaterally and left > right temporal lobes, but preserved utilisation in the frontal lobes, occipital cortices, and basal ganglia. At age 58, 62 and 68, he had quantitative neuropsychological testing, which showed a reduction in CVLT (California Verbal Learning Test) from the 84 percentile to the 1 percentile, a Stroop colour test at 16%, and auditory delayed memory at 13%. He was heterozygous for apoE4 (3/4). He noted that he had progressive difficulty recognising the faces at work, and had to have his assistants prompt him with the daily schedule. He also recalled an event in which he was several chapters into a book before he realised that it was a book he had previously read. In addition, he lost an ability he had had for most of his life: to add columns of numbers rapidly in his head.

He began Dr Dale Bredesen's program, and after six months, his wife, co-workers, and he all noted improvement. He lost 10 pounds. He was able to recognise faces at work, was able to remember his daily schedule, and was able to function at work without difficulty. He was also noted to be quicker with his responses. His life-long ability to add numbers rapidly in his head, which he had lost during his progressive cognitive decline, returned. His wife pointed out that, although he had clearly shown improvement, the more striking effect was that he had been accelerating in his decline over the prior year or two, and that this had been completely halted.

After 22 months on the program, he returned for followup quantitative neuropsychological improvement: his CVLT-IIB increased from 3rd percentile to 84th percentile (3 standard deviations), total recognised hits from < 1st percentile to 50th percentile. CVLt-II from 54th percentile to 96th percentile, auditory delayed memory from 13th to 79th percentile, reverse digit span from 24th to 74th percentile, and processing speed from 93rd to 98th percentile. His business, which had been in the process of termination, was reinvigorated, and a new site was added to the previous sites of operation.

Reversal of Cognitive Decline: A novel therapeutic program. Dale E. Bredesen. Aging, September 2014, Vol 6 N 9.