A 68 yo business executive presented with a five year history of progressive memory loss, forcing him to retire from his company. He had difficulty navigating while driving. Amyloid PET imaging was positive. His ApoE genotype was 3/4.
After six months on the programme, his BMI improved from 27.7 to 24.6, and his HbA1c improved from 5.9 to 5.7%. Both he and his family noted improvement in memory and navigation. His improvement was documented by on-line neuropsychological testing which showed increase from 0 (baseline) to 2221, which represented 52nd percentile for his age.
Reversal of cognitive decline in Alzheimer's Disease. Bredesen D. et al. Aging, June 2016, Vol 8 No 6