A 66 yo professional man presented with what he described as 'senior moments' (for example, forgetting where his keys were or forgetting appointments) of two years duration, and difficulty performing his work. There was a positive family history of dementia in both parents. He was an apoE4 heterozygote (3/4), his amyloid PET scan was markedly positive, and his FDG-PET scan showed temporoparietal reduced glucose uptake indicative of Alzheimer's Disease. An MRI showed hippocampal volume at only 17th percentile for his age. His neuropsychological testing was compatible with a diagnosis of mild cognitive decline.
He began the program, lost 18 pounds, and after three months his wife reported that his memory had improved. He noted that his work came more easily to him. However, after five months, he discontinued the majority of the program for approximately three weeks. His wife came home to find his car in the driveway, idling with the keys in the ignition, while he was inside the house, working and unaware that he had left the car idling in the driveway. He re-initiated the program, and had no further such episodes.
After ten months on the program, he returned for a followup MRI, which was subject to volumetric analysis by Neuroquant and Neuroreader programs. The former indicated an increase in hippocampal volume from 17th to 75th percentile, with an associated absolute increase in hippocampal volume of 11.7%. The Neuroreader program showed an absolute increase from 7.6 cc to 8.3 cc, which represents an 8.5% absolute increase in size.
Reversal of Cognitive Decline in Alzheimer's Disease. Dale E. Bredesen et al. Aging, June 2016, Vol 8 N 6.