A 55 yo woman presented with memory concerns of two years duration. She had a positive family history of dementia in an aunt and a grandmother. She was an ApoE4 homozygote and a TOMM40 homozygote (G/G).
She experienced difficulties with word recall several times a day, either being unable to recall the word at all or substituting the wrong word in its place. For example, she would say a word like 'tweezers' when she meant to say 'tongs' (semantic paraphrase errors). She also experienced an increase in spelling errors as she typed on her computer. As a professional writer and editor with a Master's degree in English, she found these errors very troubling. She often lost her train of thought while speaking, requiring her to ask other what she had just said, In addition, she would misplace items and forget why she had walked into an room. She would also forget somethings her husband had told her, or asked her to do.
She began the program, and after four months her husband reported that her memory has improved. She noted that her word recall was as good as it had ever been, and she was no longer experiencing an increase in spelling errors. She also reported that she rarely lost her train of thought, but if she went off on a tangent or if someone interrupted her, that issue might arise. However if she paused and give herself a few seconds, she could find her way back to her original train of thought without asking for help. In addition, she no longer forgot why she had entered a room, and only rarely misplaced items.
Her primary care provider noted that in her professional opinion, her cognition had returned to normal after four months on the protocol, and an on-line cognitive test (CNS-VS) performed prior to the start of the programming then again after five months, confirmed this opinion: her overall cognitive assessment (neurocognitive index) had increased from 16th to 73rd percentile.
Reversal of Cognitive Decline in Alzheimer's Disease. Dale E. Bredesen et al. Aging, June 2016, Vol 8 N 6.